Rabies Virus (RV) Glycoprotein Expression Levels Are Not Critical for Pathogenicity of RV

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PPEY motif within the rabies virus (RV) matrix protein is essential for efficient virion release and RV pathogenicity.

Late (L) domains containing the highly conserved sequence PPXY were first described for retroviruses, and later research confirmed their conservation and importance for efficient budding of several negative-stranded RNA viruses. Rabies virus (RV), a member of the Rhabdoviridae family, contains the sequence PPEY (amino acids 35 to 38) within the N terminus of the matrix (M) protein, but the func...

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ژورنال

عنوان ژورنال: Journal of Virology

سال: 2010

ISSN: 0022-538X

DOI: 10.1128/jvi.01309-10